But his body may handle fluids differently, and he may need to pay more attention to staying well hydrated—especially during exercise, heat exposure, or illness. Based on all available evidence, there is no direct scientific proof that TRT causes dehydration in a typical patient. Finally, TRT can be given in different forms—injections, gels, patches, or pellets—and each one affects hormone levels differently. It becomes hard to tell if any fluid changes come from TRT itself or from the person’s underlying health. In a review of creatine supplementation studies, Persky and Rawson found no increase in serum creatinine in 12 studies, 8 studies showed an increase that remained within the normal range, and only 2 studies showed an increase above normal limits (although not different from the control group in one study). Both blood and urinary creatinine may be increased by ingestion of creatine supplementation and creatine containing foods, such as meat. However, the amount of creatinine in the blood is related to muscle mass (i.e. males have higher blood creatinine than females) and both dietary creatine and creatinine intake . As a result, creatine supplementation may not lead to water retention. The water retention picture is different from bulking compounds. Some users report modest improvements in lean mass retention during a caloric deficit, which is one of the more credible applications in both clinical and anecdotal contexts. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Ask us about TRT, medical weightloss, ED, or other men's health topics. For example, some studies suggest that TRT decreases your risk of heart attack over time, while others say it increases your risk. If you stop taking testosterone, your body will have to recover its ability to make testosterone again. This means that you’ll need the medication to continue having a normal level of testosterone in your body. With TRT, you take a manufactured form of testosterone to regulate your levels. Before starting TRT, your healthcare provider will make sure low testosterone is an accurate diagnosis. Testosterone replacement therapy (TRT) can help improve the symptoms of low testosterone due to male hypogonadism. Even with an abnormally low level that is replicated on a repeat test, the decision to begin testosterone replacement therapy and the proper dose requires a careful conversation with your doctor. Testosterone therapy does not appear to increase the risk of prostate cancer, but it can stimulate the growth of prostate cancer cells. Questions and concerns involving creatine supplementation and kidney damage/renal dysfunction are common. This increase in MPS is due to testosterone’s ability to enter the muscle cell, bind with the intracellular androgen receptor, and increase the expression of various muscle-specific genes . It is important to highlight that the ICW is an important cellular signal for protein synthesis and thus drives an increase in muscle mass over time .
