One or two 5mg non-genital testosterone patches can be applied nightly over the skin of the back, thigh, or upper arm (away from pressure areas). According to Paduch et al., there is no "universally accepted threshold of Testosterone (T) concentration that distinguishes eugonadal from hypogonadal men" and, therefore, no current standard of care guidelines for the treatment of hypogonadism . Male hypogonadism is characterized by a deficiency in the body’s innate ability to produce testosterone, usually due to some dysfunction of the hypothalamic-pituitary-gonadal axis. According to our research and statistical analyses, we have concluded that oral administration has shown to be as advantageous as other modalities for male hypogonadism. The treatment did not exhibit any adverse side effects on the prostate gland, including prostate-specific antigen. Oral administration of testosterone undecanoate is an effective method to achieve therapeutic physiological levels of serum testosterone in patients with hypogonadism. If you have low testosterone symptoms, talk to your doctor about ways to boost levels such as hormone replacement therapy. Geriatric patients treated with androgens may also be at risk for worsening of signs and symptoms of BPH and hypertension. Evaluate patients for prostate cancer, including measurement of prostate specific antigen (PSA), prior to initiating and during treatment with androgens These BP increases can increase the risk of major adverse cardiovascular events (MACE), with greater risk in patients with established cardiovascular disease or risk factors for cardiovascular disease. Results from the TRAVERSE trial were submitted in 2023, concluding that there was no increase in the risk of adverse cardiovascular outcomes in men using testosterone for hypogonadism.
